Search on: PROTEINASE INHIBITORY PROTEINS, SECRETORY 
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Descriptor English:   Proteinase Inhibitory Proteins, Secretory 
Descriptor Spanish:   Proteínas Inhibidoras de Proteinasas Secretoras 
Descriptor Portuguese:   Proteínas Secretadas Inibidoras de Proteinases 
Synonyms English:   Neutrophil Elastase Inhibitors
Proteinase Inhibitory Peptides, Secretory  
Tree Number:   D12.644.822
D12.776.645
Definition English:   Peptides and proteins found in BODILY SECRETIONS and BODY FLUIDS that are PROTEASE INHIBITORS. They play a role in INFLAMMATION, tissue repair and innate immunity (IMMUNITY, INNATE) by inhibiting endogenous proteinases such as those produced by LEUKOCYTES and exogenous proteases such as those produced by invading microorganisms. 
Pharmacological Action:   Protease Inhibitors
 
See Related English:   Protease Inhibitors
 
History Note English:   2007(1980) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   52317 
Unique Identifier:   D053491 

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